A phase 1b randomised, placebo-controlled trial of nabiximols cannabinoid oromucosal spray with temozolomide in patients with recurrent glioblastoma

BACKGROUND: Preclinical data suggest some cannabinoids may exert antitumour effects against glioblastoma (GBM). Safety and preliminary efficacy of nabiximols oromucosal cannabinoid spray plus dose-intense temozolomide (DIT) was evaluated in patients with first recurrence of GBM. METHODS: Part 1 was...

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Veröffentlicht in:Br J Cancer
Hauptverfasser: Twelves, Chris, Sabel, Michael, Checketts, Daniel, Miller, Sharon, Tayo, Bola, Jove, Maria, Brazil, Lucy, Short, Susan C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8039032/
https://ncbi.nlm.nih.gov/pubmed/33623076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-021-01259-3
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