Development and Validation of a Chiral Liquid Chromatographic Assay for Enantiomeric Separation and Quantification of Verapamil in Rat Plasma: Stereoselective Pharmacokinetic Application

A novel, fast and sensitive enantioselective HPLC assay with a new core–shell isopropyl carbamate cyclofructan 6 (superficially porous particle, SPP) chiral column (LarihcShell-P, LSP) was developed and validated for the enantiomeric separation and quantification of verapamil (VER) in rat plasma. Th...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Mohammed, Mostafa S., Hefnawy, Mohamed M., Al-Majed, Abdulrhman A., Alrabiah, Haitham K., Algrain, Nasser A., Obaidullah, Ahmad J., Altamimi, Abdulmalik S., Bin Jardan, Yousef A., Al-Hossaini, Abdullah M.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8038655/
https://ncbi.nlm.nih.gov/pubmed/33917412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26072091
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