Bis-3-Chloropiperidines Targeting TAR RNA as A Novel Strategy to Impair the HIV-1 Nucleocapsid Protein

Specific RNA sequences regulate functions essential to life. The Trans-Activation Response element (TAR) is an RNA stem–bulge–loop structure involved in several steps of HIV-1 replication. In this work, we show how RNA targeting can inhibit HIV-1 nucleocapsid (NC), a highly conserved protein known t...

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Bibliographic Details
Published in:Molecules
Main Authors: Sosic, Alice, Olivato, Giulia, Carraro, Caterina, Göttlich, Richard, Fabris, Dan, Gatto, Barbara
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8038054/
https://ncbi.nlm.nih.gov/pubmed/33810333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26071874
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