Synthesis and Rational Design of New Appended 1,2,3-Triazole-uracil Ensembles as Promising Anti-Tumor Agents via In Silico VEGFR-2 Transferase Inhibition

Angiogenesis inhibition is a key step towards the designing of new chemotherapeutic agents. In a view to preparing new molecular entities for cancer treatment, eighteen 1,2,3-triazole-uracil ensembles 5a–r were designed and synthesized via the click reaction. The ligands were well characterized usin...

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Vydáno v:Molecules
Hlavní autoři: Reddy, Nadipolla Naresh, Hung, Sung-Jen, Swamy, Merugu Kumara, Sanjeev, Ananthula, Rao, Vankadari Srinivasa, Rohini, Rondla, Raju, Atcha Krishnam, Bhaskar, Kuthati, Hu, Anren, Reddy, Puchakayala Muralidhar
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8037033/
https://ncbi.nlm.nih.gov/pubmed/33808444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26071952
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