m(6)A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype

Methyltransferase-like 3 (METTL3) and 14 (METTL14) are core subunits of the methyltransferase complex (MTC) that catalyzes mRNA N(6)-methyladenosine (m(6)A) modification. Despite the expanding list of m(6)A-dependent function of the MTC, m(6)A independent function of the METTL3 and METTL14 complex r...

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Pubblicato in:Nat Cell Biol
Autori principali: Liu, Pingyu, Li, Fuming, Lin, Jianhuang, Fukumoto, Takeshi, Nacarelli, Timothy, Hao, Xue, Kossenkov, Andrew V., Simon, M. Celeste, Zhang, Rugang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8035315/
https://ncbi.nlm.nih.gov/pubmed/33795874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-021-00656-3
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