Frustrated folding of guanine quadruplexes in telomeric DNA

Human chromosomes terminate in long, single-stranded, DNA overhangs of the repetitive sequence (TTAGGG)n. Sets of four adjacent TTAGGG repeats can fold into guanine quadruplexes (GQ), four-stranded structures that are implicated in telomere maintenance and cell immortalization and are targets in can...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Carrino, Simone, Hennecker, Christopher D, Murrieta, Ana C, Mittermaier, Anthony
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
Chemical Biology and Nucleic Acid Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034632/
https://ncbi.nlm.nih.gov/pubmed/33693924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab140
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