The inhibitory receptor Tim-3 fails to suppress IFN-γ production via the NFAT pathway in NK-cell, unlike that in CD4(+) T cells

BACKGROUND: T cell immunoglobulin and mucin domain-containing-3 (Tim-3) is a negative regulator expressed on T cells, and is also expressed on natural killer (NK) cells. The function of Tim-3 chiefly restricts IFNγ-production in T cells, however, the impact of Tim-3 on NK cell function has not been...

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Pubblicato in:BMC Immunol
Autori principali: Yu, Xiaowen, Lang, Bin, Chen, Xi, Tian, Yao, Qian, Shi, Zhang, Zining, Fu, Yajing, Xu, Junjie, Han, Xiaoxu, Ding, Haibo, Jiang, Yongjun
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034152/
https://ncbi.nlm.nih.gov/pubmed/33832435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-021-00417-9
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