Integrated Multi-Omic Analyses of the Genomic Modifications by Gut Microbiome-Derived Metabolites of Epicatechin, 5-(4′-Hydroxyphenyl)-γ-Valerolactone, in TNFalpha-Stimulated Primary Human Brain Microvascular Endothelial Cells

Cerebral blood vessels are lined with endothelial cells and form the blood-brain barrier. Their dysfunction constitutes a crucial event in the physiopathology of neurodegenerative disorders and cognitive impairment. Epicatechin can improve cognitive functions and lower the risk for Alzheimer’s disea...

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Bibliographische Detailangaben
Veröffentlicht in:Front Neurosci
Hauptverfasser: Corral-Jara, Karla Fabiola, Nuthikattu, Saivageethi, Rutledge, John, Villablanca, Amparo, Morand, Christine, Schroeter, Hagen, Milenkovic, Dragan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033932/
https://ncbi.nlm.nih.gov/pubmed/33841078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2021.622640
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