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Adenosine Kinase Expression Determines DNA Methylation in Cancer Cell Lines

[Image: see text] DNA methylation has a major role in cancer, and its inhibitors are used therapeutically. DNA methylation depends on methyl group flux through the transmethylation pathway, which forms adenosine. We hypothesized that an adenosine kinase isoform with nuclear expression (ADK-L) determ...

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Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Wahba, Amir E., Fedele, Denise, Gebril, Hoda, AlHarfoush, Enmar, Toti, Kiran S., Jacobson, Kenneth A., Boison, Detlev
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033756/
https://ncbi.nlm.nih.gov/pubmed/33860193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.1c00008
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