AB016. A double-blind, placebo-controlled, phase 2 trial of a novel toll-like receptor 7/8/9 antagonist (IMO-8400) in dermatomyositis

BACKGROUND: Dermatomyositis (DM) is an inflammatory disease of skin and muscle. Increased interferon (IFN) signaling is a prominent feature of DM, but the mechanisms leading to IFN production in DM are not understood. As toll-like receptor (TLR) 7/8/9 activation can lead to type I IFN production, TL...

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Detalhes bibliográficos
Publicado no:Ann Transl Med
Main Authors: Kim, Yoo Jung, Schiopu, Elena, Dankó, Katalin, Mozaffar, Tahseen, Chunduru, Srinivas, Lees, Kirstin, Goyal, Namita, Sarazin, Jeffrey, Fiorentino, David F., Sarin, Kavita Y.
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2021
Assuntos:
Abstract on Rheumatologic Skin Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033384/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2021.AB016
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