VEGFR Inhibitors for Uterine Metastatic Perivascular Epithelioid Tumors (PEComa) Resistant to mTOR Inhibitors. A Case Report and Review of Literature

Uterine perivascular epithelioid cell tumors (PEComas) are rare neoplasms. PI3K/AKT/mTOR pathway upregulation is critical for their pathogenesis and is often associated with TSC1/TSC2 inactivation. Although first line mTOR inhibitors are an effective treatment, metastatic PEComas eventually progress...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Liapi, Aikaterini, Mathevet, Patrice, Herrera, Fernanda G., Hastir, Delfyne, Sarivalasis, Apostolos
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032946/
https://ncbi.nlm.nih.gov/pubmed/33842348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.641376
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