Conversion of Reactive Astrocytes to Induced Neurons Enhances Neuronal Repair and Functional Recovery After Ischemic Stroke

The master neuronal transcription factor NeuroD1 can directly reprogram astrocytes into induced neurons (iNeurons) after stroke. Using viral vectors to drive ectopic ND1 expression in gliotic astrocytes after brain injury presents an autologous form of cell therapy for neurodegenerative disease. Cul...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Aging Neurosci
Päätekijät: Jiang, Michael Qize, Yu, Shan Ping, Wei, Zheng Zachory, Zhong, Weiwei, Cao, Wenyuan, Gu, Xiaohuan, Wu, Anika, McCrary, Myles Randolph, Berglund, Ken, Wei, Ling
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2021
Aiheet:
Neuroscience
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032905/
https://ncbi.nlm.nih.gov/pubmed/33841125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2021.612856
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