Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites

Smc5/6 is essential for genome structural integrity by yet unknown mechanisms. Here we find that Smc5/6 co-localizes with the DNA crossed-strand processing complex Sgs1-Top3-Rmi1 (STR) at genomic regions known as natural pausing sites (NPSs) where it facilitates Top3 retention. Individual depletions...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Agashe, Sumedha, Joseph, Chinnu Rose, Reyes, Teresa Anne Clarisse, Menolfi, Demis, Giannattasio, Michele, Waizenegger, Anja, Szakal, Barnabas, Branzei, Dana
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032827/
https://ncbi.nlm.nih.gov/pubmed/33833229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22217-w
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