mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they have to be stored at (ultra)low temperatures. Understanding the root cause of the instability of these vaccines may help to rationally improve mRNA-LNP product stability and thereby ease the temperature conditions...

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Detalhes bibliográficos
Publicado no:Int J Pharm
Main Authors: Schoenmaker, Linde, Witzigmann, Dominik, Kulkarni, Jayesh A., Verbeke, Rein, Kersten, Gideon, Jiskoot, Wim, Crommelin, Daan J.A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Author(s). Published by Elsevier B.V. 2021
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032477/
https://ncbi.nlm.nih.gov/pubmed/33839230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2021.120586
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