Accelerated Tau Aggregation, Apoptosis and Neurological Dysfunction Caused by Chronic Oral Administration of Aluminum in a Mouse Model of Tauopathies

To clarify whether long‐term oral ingestion of aluminum (Al) can increase tau aggregation in mammals, we examined the effects of oral Al administration on tau accumulation, apoptosis in the central nervous system (CNS) and motor function using tau transgenic (Tg) mice that show very slowly progressi...

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Bibliographic Details
Published in:Brain Pathol
Main Authors: Oshima, Etsuko, Ishihara, Takeshi, Yokota, Osamu, Nakashima‐Yasuda, Hanae, Nagao, Shigeto, Ikeda, Chikako, Naohara, Jun, Terada, Seishi, Uchitomi, Yosuke
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2013
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8028981/
https://ncbi.nlm.nih.gov/pubmed/23574527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12059
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