Detection of 2‐Hydroxyglutarate in Formalin‐Fixed Paraffin‐Embedded Glioma Specimens by Gas Chromatography/Mass Spectrometry

Mutations in the isocitrate dehydrogenase (IDH) 1 and 2 genes occur frequently in diffuse astrocytoma and oligodendroglioma. The consecutive amino acid substitutions in the mutant proteins result in a gain of the function to catalyze the reduction of alpha‐ketoglutarate to 2‐hydroxyglutarate (2HG)....

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Bibliographic Details
Published in:Brain Pathol
Main Authors: Sahm, Felix, Capper, David, Pusch, Stefan, Balss, Jörg, Koch, Arend, Langhans, Claus‐Dieter, Okun, Jürgen G., von Deimling, Andreas
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2011
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Technical Advances
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8028858/
https://ncbi.nlm.nih.gov/pubmed/21631627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2011.00506.x
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