Benzothiazole Amides as TRPC3/6 Inhibitors for Gastric Cancer Treatment

[Image: see text] Transient receptor potential canonical channel 6 (TRPC6) has been implicated in many kinds of malignant tumors, but very few potent TRPC6 antagonists are available. In this study, a benzothiazole amide derivative 1a was discovered as a TRPC6 activator in a cell-based high-throughpu...

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Détails bibliographiques
Publié dans:ACS Omega
Auteurs principaux: Wei, Yingjie, Zhang, Mengxian, Lyu, Zhenbin, Yang, Guolin, Tian, Tian, Ding, Mingmin, Zeng, Xiaodong, Xu, Fuchun, Wang, Pengyu, Li, Fangfang, Liu, Yixuan, Cao, Zhengyu, Lu, Jing, Hong, Xuechuan, Wang, Hongbo
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2021
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8028158/
https://ncbi.nlm.nih.gov/pubmed/33842788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.1c00514
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