Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients

Human-induced pluripotent stem cells (hiPSCs) allow for the establishment of brain cellular models of psychiatric disorders that account for a patient’s genetic background. Here, we conducted an RNA-sequencing profiling study of hiPSC-derived cell lines from schizophrenia (SCZ) subjects, most of whi...

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Vydáno v:Neuropsychopharmacology
Hlavní autoři: Stertz, Laura, Di Re, Jessica, Pei, Guangsheng, Fries, Gabriel R., Mendez, Emily, Li, Shenglan, Smith-Callahan, Laura, Raventos, Henriette, Tipo, Jerricho, Cherukuru, Rohan, Zhao, Zhongming, Liu, Ying, Jia, Peilin, Laezza, Fernanda, Walss-Bass, Consuelo
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027596/
https://ncbi.nlm.nih.gov/pubmed/33288841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-020-00924-0
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