AIM2 Inhibits BRAF-Mutant Colorectal Cancer Growth in a Caspase-1-Dependent Manner

Absent in melanoma 2 (AIM2), a DNA sensor that plays an important role in natural immunity system, has been reported to participate in colorectal cancer (CRC) development. However, the functional role of AIM2 in BRAF-mutant CRC remains unclear. In this study, we first investigated AIM2 expression le...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Shah, Shailendra, Qin, Shaolan, Luo, Yang, Huang, Yizhou, Jing, Ran, Shah, Jay N., Chen, Jianjun, Chen, Huimin, Zhong, Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027362/
https://ncbi.nlm.nih.gov/pubmed/33842454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.588278
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