An electrochemical method for detecting the biomarker 4-HPA by allosteric activation of Acinetobacterbaumannii reductase C1 subunit

The C1 (reductase) subunit of 4-hydroxy-phenylacetate (4-HPA) 3-hydroxylase (HPAH) from the soil-based bacterium Acinetobacterbaumannii catalyzes NADH oxidation by molecular oxygen, with hydrogen peroxide as a by-product. 4-HPA is a potent allosteric modulator of C1, but also a known urinary biomark...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Teanphonkrang, Somjai, Suginta, Wipa, Sucharitakul, Jeerus, Fukamizo, Tamo, Chaiyen, Pimchai, Schulte, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027283/
https://ncbi.nlm.nih.gov/pubmed/33639166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100467
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