Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1

OBJECTIVE: Monoacylglycerol acyltransferase (MGAT) enzymes catalyze the synthesis of diacylglycerol from monoacylglycerol. Previous work has suggested the importance of MGAT activity in the development of obesity-related hepatic insulin resistance. Indeed, antisense oligonucleotide (ASO)-mediated kn...

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Vydáno v:Mol Metab
Hlavní autoři: Lutkewitte, Andrew J., Singer, Jason M., Shew, Trevor M., Martino, Michael R., Hall, Angela M., He, Mai, Finck, Brian N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027266/
https://ncbi.nlm.nih.gov/pubmed/33676028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2021.101204
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