Colonic Gene Expression and Fecal Microbiota in Diarrhea-predominant Irritable Bowel Syndrome: Increased Toll-like Receptor 4 but Minimal Inflammation and no Response to Mesalazine

BACKGROUND/AIMS: Diarrhea-predominant irritable bowel syndrome (IBS-D) has been previously associated with evidence of immune activation and altered microbiota. Our aim is to assess the effect of the anti-inflammatory agent, mesalazine, on inflammatory gene expression and microbiota composition in I...

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Veröffentlicht in:J Neurogastroenterol Motil
Hauptverfasser: Jalanka, Jonna, Lam, Ching, Bennett, Andrew, Hartikainen, Anna, Crispie, Fiona, Finnegan, Laura A, Cotter, Paul D, Spiller, Robin
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Korean Society of Neurogastroenterology and Motility 2021
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026366/
https://ncbi.nlm.nih.gov/pubmed/33795545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5056/jnm20205
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