Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer’s disease

A variety of Alzheimer’s disease (AD) mouse models overexpress mutant forms of human amyloid precursor protein (APP), producing high levels of amyloid β (Aβ) and forming plaques. However, the degree to which these models mimic spatiotemporal patterns of Aβ deposition in brains of AD patients is unkn...

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Detalhes bibliográficos
Publicado no:J Comp Neurol
Main Authors: Whitesell, Jennifer D., Buckley, Alex R., Knox, Joseph E., Kuan, Leonard, Graddis, Nile, Pelos, Andrew, Mukora, Alice, Wakeman, Wayne, Bohn, Phillip, Ho, Anh, Hirokawa, Karla E., Harris, Julie A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026112/
https://ncbi.nlm.nih.gov/pubmed/30311654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cne.24555
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