Estimation of nonlinear differential equation model for glucose-insulin dynamics in type I diabetic patients using generalized smoothing

In this work, we develop an ordinary differential equations (ODE) model of physiological regulation of glycemia in type 1 diabetes mellitus (T1DM) patients in response to meals and intravenous insulin infusion. Unlike for majority of existing mathematical models of glucose-insulin dynamics, paramete...

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Bibliographic Details
Published in:Ann Appl Stat
Main Authors: Chervoneva, Inna, Freydin, Boris, Hipszer, Brian, Apanasovich, Tatiyana V., Joseph, Jeffrey I
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025877/
https://ncbi.nlm.nih.gov/pubmed/33833847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1214/13-aoas706
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