Identification of Critical Residues in the Carboxy Terminus of the Dopamine Transporter Involved in the G Protein βγ-Induced Dopamine Efflux

The dopamine transporter (DAT) plays a crucial role in the regulation of brain dopamine (DA) homeostasis through the re-uptake of DA back into the presynaptic terminal. In addition to re-uptake, DAT is also able to release DA through a process referred to as DAT-mediated DA efflux. This is the mecha...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Pino, José A., Nuñez-Vivanco, Gabriel, Hidalgo, Gabriela, Reyes Parada, Miguel, Khoshbouei, Habibeh, Torres, Gonzalo E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025876/
https://ncbi.nlm.nih.gov/pubmed/33841159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.642881
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