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Endosomal Recycling Reconciles the Alzheimer’s Paradox
We propose a hub-and-spoke model of Alzheimer’s disease, with endosomal recycling acting as the pathogenic hub from where the disease’s other pathologies fan out, thereby providing a role for the amyloid-precursor protein and reconciling a paradox caused by mounting questions over the ‘amyloid casca...
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| Udgivet i: | Sci Transl Med |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8025181/ https://ncbi.nlm.nih.gov/pubmed/33268506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abb1717 |
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