Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies

OBJECTIVE: REM-sleep behavior disorder (RBD) is a prodromal synucleinopathy, as >80% will eventually convert to overt synucleinopathy. We performed an in-depth analysis of the SNCA locus to identify RBD-specific risk variants. METHODS: Full sequencing and genotyping of SNCA was performed in isola...

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Publié dans:Ann Neurol
Auteurs principaux: Krohn, Lynne, Wu, Richard YJ, Heilbron, Karl, Ruskey, Jennifer A., Laurent, Sandra B., Blauwendraat, Cornelis, Alam, Armaghan, Arnulf, Isabelle, Hu, Michele T.M., Dauvilliers, Yves, Högl, Birgit, Toft, Mathias, Bjørnarå, Kari Anne, Stefani, Ambra, Holzknecht, Evi, Monaca, Christelle Charley, Beatriz, Abril, Plazzi, Giuseppe, Antelmi, Elena, Ferini-Strambi, Luigi, Young, Peter, Heidbreder, Anna, Cochen De Cock, Valérie, Mollenhauer, Brit, Sixel-Döring, Friederike, Trenkwalder, Claudia, Sonka, Karel, Kemlink, David, Figorilli, Michela, Puligheddu, Monica, Dijkstra, Femke, Viaene, Mineke, Oertel, Wolfang, Toffoli, Marco, Gigli, Gian Luigi, Valente, Mariarosaria, Gagnon, Jean-François, Nalls, Mike A., Singleton, Andrew B., Desautels, Alex, Montplaisir, Jacques Y., Cannon, Paul, Ross, Owen A., Boeve, Bradley F., Dupré, Nicolas, Fon, Edward A., Postuma, Ronald B., Pihlstrøm, Lasse, Rouleau, Guy A., Gan-Or, Ziv
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025046/
https://ncbi.nlm.nih.gov/pubmed/31976583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25687
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