Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies

OBJECTIVE: REM-sleep behavior disorder (RBD) is a prodromal synucleinopathy, as >80% will eventually convert to overt synucleinopathy. We performed an in-depth analysis of the SNCA locus to identify RBD-specific risk variants. METHODS: Full sequencing and genotyping of SNCA was performed in isola...

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Publicado no:Ann Neurol
Main Authors: Krohn, Lynne, Wu, Richard YJ, Heilbron, Karl, Ruskey, Jennifer A., Laurent, Sandra B., Blauwendraat, Cornelis, Alam, Armaghan, Arnulf, Isabelle, Hu, Michele T.M., Dauvilliers, Yves, Högl, Birgit, Toft, Mathias, Bjørnarå, Kari Anne, Stefani, Ambra, Holzknecht, Evi, Monaca, Christelle Charley, Beatriz, Abril, Plazzi, Giuseppe, Antelmi, Elena, Ferini-Strambi, Luigi, Young, Peter, Heidbreder, Anna, Cochen De Cock, Valérie, Mollenhauer, Brit, Sixel-Döring, Friederike, Trenkwalder, Claudia, Sonka, Karel, Kemlink, David, Figorilli, Michela, Puligheddu, Monica, Dijkstra, Femke, Viaene, Mineke, Oertel, Wolfang, Toffoli, Marco, Gigli, Gian Luigi, Valente, Mariarosaria, Gagnon, Jean-François, Nalls, Mike A., Singleton, Andrew B., Desautels, Alex, Montplaisir, Jacques Y., Cannon, Paul, Ross, Owen A., Boeve, Bradley F., Dupré, Nicolas, Fon, Edward A., Postuma, Ronald B., Pihlstrøm, Lasse, Rouleau, Guy A., Gan-Or, Ziv
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025046/
https://ncbi.nlm.nih.gov/pubmed/31976583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25687
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