The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway

BACKGROUND AND AIMS: TRIM21 is a ubiquitin E3 ligase that is implicated in numerous biological processes including immune response, cell metabolism, redox homeostasis, and cancer development. We recently reported that TRIM21 can negatively regulate the p62-Keap1-Nrf2 antioxidant pathway by ubiquityl...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Wang, Fang, Zhang, Ye, Shen, Jianliang, Yang, Bin, Dai, Weiwei, Yan, Junrong, Maimouni, Sara, Daguplo, Heineken Q., Coppola, Sara, Gao, Yingtang, Wang, Yijun, Du, Zhi, Peng, Kesong, Liu, Hui, Zhang, Qin, Tang, Fei, Wang, Peng, Gao, Shenglan, Wang, Yongbo, Ding, Wen-Xing, Guo, Grace, Wang, Fengmei, Zong, Wei-Xing
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024979/
https://ncbi.nlm.nih.gov/pubmed/33482392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2021.01.007
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