Distinct roles and actions of protein disulfide isomerase family enzymes in catalysis of nascent-chain disulfide bond formation

The mammalian endoplasmic reticulum (ER) harbors more than 20 members of the protein disulfide isomerase (PDI) family that act to maintain proteostasis. Herein, we developed an in vitro system for directly monitoring PDI- or ERp46-catalyzed disulfide bond formation in ribosome-associated nascent cha...

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Publicado en:iScience
Main Authors: Hirayama, Chihiro, Machida, Kodai, Noi, Kentaro, Murakawa, Tadayoshi, Okumura, Masaki, Ogura, Teru, Imataka, Hiroaki, Inaba, Kenji
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024706/
https://ncbi.nlm.nih.gov/pubmed/33855279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102296
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