Effect of Fluorofenidone Against Paraquat-Induced Pulmonary Fibrosis Based on Metabolomics and Network Pharmacology

BACKGROUND: Fluorofenidone (AKF-PD) is an anti-fibrotic small-molecule compound. Its mechanism of action on paraquat (PQ)-induced pulmonary fibrosis is still unclear. MATERIAL/METHODS: Forty-eight SD rats were divided into 4 groups: control group, PQ group, PQ+AKF-PD group, and AKF-PD group. The pat...

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Bibliografiske detaljer
Udgivet i:Med Sci Monit
Main Authors: Jiang, Feiya, Wang, Tongtong, Li, Sha, Jiang, Yu, Chen, Zhuo, Liua, Wen
Format: Artigo
Sprog:Inglês
Udgivet: International Scientific Literature, Inc. 2021
Fag:
Animal Study
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8023277/
https://ncbi.nlm.nih.gov/pubmed/33790218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.930166
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