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Revisiting the genome-wide significance threshold for common variant GWAS

Over the last decade, GWAS meta-analyses have used a strict P-value threshold of 5 × 10(−8) to classify associations as significant. Here, we use our current understanding of frequently studied traits including lipid levels, height, and BMI to revisit this genome-wide significance threshold. We comp...

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Uloženo v:
Podrobná bibliografie
Vydáno v:G3 (Bethesda)
Hlavní autoři: Chen, Zhongsheng, Boehnke, Michael, Wen, Xiaoquan, Mukherjee, Bhramar
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022962/
https://ncbi.nlm.nih.gov/pubmed/33585870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/g3journal/jkaa056
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