The etiology of Down syndrome: Maternal MCM9 polymorphisms increase risk of reduced recombination and nondisjunction of chromosome 21 during meiosis I within oocyte

Altered patterns of recombination on 21q have long been associated with the nondisjunction chromosome 21 within oocytes and the increased risk of having a child with Down syndrome. Unfortunately the genetic etiology of these altered patterns of recombination have yet to be elucidated. We for the fir...

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Udgivet i:PLoS Genet
Main Authors: Pal, Upamanyu, Halder, Pinku, Ray, Anirban, Sarkar, Sumantra, Datta, Supratim, Ghosh, Papiya, Ghosh, Sujay
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8021012/
https://ncbi.nlm.nih.gov/pubmed/33750944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009462
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