Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravis

Human immunoglobulin (Ig) G4 usually displays antiinflammatory activity, and observations of IgG4 autoantibodies causing severe autoimmune disorders are therefore poorly understood. In blood, IgG4 naturally engages in a stochastic process termed “Fab-arm exchange” in which unrelated IgG4s exchange h...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Vergoossen, Dana L. E., Plomp, Jaap J., Gstöttner, Christoph, Fillié-Grijpma, Yvonne E., Augustinus, Roy, Verpalen, Robyn, Wuhrer, Manfred, Parren, Paul W. H. I., Dominguez-Vega, Elena, van der Maarel, Silvère M., Verschuuren, Jan J., Huijbers, Maartje G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2021
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020787/
https://ncbi.nlm.nih.gov/pubmed/33753489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020635118
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