Antiaging gene Klotho regulates epithelial-mesenchymal transition and increases sensitivity to pemetrexed by inducing lipocalin-2 expression

Epithelial-mesenchymal transition (EMT) is considered to serve an important role in the metastatic/invasive ability of cancer cells, in the acquisition of drug resistance, and in metabolic reprogramming. In the present study, it was hypothesized that the Klotho gene is involved in the metastatic/inv...

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Vydáno v:Oncol Lett
Hlavní autoři: Takegahara, Kyoshiro, Usuda, Jitsuo, Inoue, Tatsuya, Sonokawa, Takumi, Matsui, Takuma, Matsumoto, Mitsuo
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020392/
https://ncbi.nlm.nih.gov/pubmed/33841579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2021.12679
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