Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia–reperfusion injury

INTRODUCTION: Inflammation is a key factor in myocardial ischemia/reperfusion (MI/R) injury. Targeting leucocyte-mediated inflammation is an important strategy for MI/R therapy. Iminostilbene (ISB), a simple dibenzoazepine small molecule compound, has a strong anti-neurodegenerative effect. However,...

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Udgivet i:J Adv Res
Main Authors: Lu, Shan, Tian, Yu, Luo, Yun, Xu, Xudong, Ge, Wenxiu, Sun, Guibo, Sun, Xiaobo
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Basic and Biological Science
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020153/
https://ncbi.nlm.nih.gov/pubmed/33842007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jare.2020.09.001
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