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To protect and modify double-stranded RNA – the critical roles of ADARs in development, immunity and oncogenesis
Adenosine deaminases that act on RNA (ADARs) are present in all animals and function to both bind double-stranded RNA (dsRNA) and catalyze the deamination of adenosine (A) to inosine (I). As inosine is a biological mimic of guanosine, deamination by ADARs changes the genetic information in the RNA s...
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| Udgivet i: | Crit Rev Biochem Mol Biol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8019592/ https://ncbi.nlm.nih.gov/pubmed/33356612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10409238.2020.1856768 |
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