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Tobacco Smoke Exposure Limits the Therapeutic Benefit of Tezacaftor/Ivacaftor in Pediatric Patients with Cystic Fibrosis
OBJECTIVES: Tobacco smoke exposure reduces CFTR functional expression in vitro and contributes to acquired CFTR dysfunction. We investigated whether it also inhibits the clinical benefit of CFTR modulators, focusing on tezacaftor/ivacaftor, approved in February 2018 for individuals with CF age ≥12 y...
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| Izdano u: | J Cyst Fibros |
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| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8018981/ https://ncbi.nlm.nih.gov/pubmed/33023836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcf.2020.09.011 |
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