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Absence of retbindin blocks glycolytic flux, disrupts metabolic homeostasis, and leads to photoreceptor degeneration

We previously reported a model of progressive retinal degeneration resulting from the knockout of the retina-specific riboflavin binding protein, retbindin (Rtbdn(−/−)). We also demonstrated a reduction in neural retinal flavins as a result of the elimination of RTBDN. Given the role of flavins in m...

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Sinha, Tirthankar, Du, Jianhai, Makia, Mustafa S., Hurley, James B., Naash, Muna I., Al-Ubaidi, Muayyad R.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017963/
https://ncbi.nlm.nih.gov/pubmed/33526685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2018956118
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