Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta-CoV that recently emerged as a human pathogen and is the causative agent of the COVID-19 pandemic. A molecular framework of how the virus manipulates host cellular machinery to facilitate infection remains unclear. Here, we focus...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Lapointe, Christopher P., Grosely, Rosslyn, Johnson, Alex G., Wang, Jinfan, Fernández, Israel S., Puglisi, Joseph D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017934/
https://ncbi.nlm.nih.gov/pubmed/33479166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017715118
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