NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers

PURPOSE: Downregulation of MHC class I (MHC-I) is a common immune evasion strategy of many cancers. Similarly, two allogeneic clonal transmissible cancers have killed thousands of wild Tasmanian devils (Sarcophilus harrisii) and also modulate MHC-I expression to evade anti-cancer and allograft respo...

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Gepubliceerd in:J Cancer Res Clin Oncol
Hoofdauteurs: Ong, Chrissie E. B., Patchett, Amanda L., Darby, Jocelyn M., Chen, Jinying, Liu, Guei-Sheung, Lyons, A. Bruce, Woods, Gregory M., Flies, Andrew S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Berlin Heidelberg 2021
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Original Article – Cancer Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017436/
https://ncbi.nlm.nih.gov/pubmed/33797607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-021-03601-x
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