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Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver

The adult liver has an exceptional ability to regenerate, but how it maintains its specialized functions during regeneration is unclear. Here, we used partial hepatectomy (PHx) in tandem with single-cell transcriptomics to track cellular transitions and heterogeneities of ∼22,000 liver cells through...

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Détails bibliographiques
Publié dans:Genome Res
Auteurs principaux: Chembazhi, Ullas V., Bangru, Sushant, Hernaez, Mikel, Kalsotra, Auinash
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8015853/
https://ncbi.nlm.nih.gov/pubmed/33649154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.267013.120
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