RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress

Aneuploidy, defined as whole-chromosome gain or loss, causes cellular stress but, paradoxically, is a frequent occurrence in cancers. Here, we investigate why ∼50% of Ewing sarcomas, driven by the EWS-FLI1 fusion oncogene, harbor chromosome 8 gains. Expression of the EWS-FLI1 fusion in primary cells...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Su, Xiaofeng A., Ma, Duanduan, Parsons, James V., Replogle, John M., Amatruda, James F., Whittaker, Charles A., Stegmaier, Kimberly, Amon, Angelika
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8015718/
https://ncbi.nlm.nih.gov/pubmed/33766983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.345454.120
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