HPV+ oropharyngeal squamous cell carcinomas from patients with two tumors display synchrony of viral genomes yet discordant mutational profiles and signatures

Human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (HPV + OPSCC) is increasing in prevalence in the USA, as are cases of patients with multiple HPV + OPSCCs (mHPV + OPSCC). mHPV + OPSCCs present a unique opportunity to examine HPV + OPSCC mutation acquisition and evolution. We...

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Detalhes bibliográficos
Publicado no:Carcinogenesis
Main Authors: Faden, Daniel L, Langenbucher, Adam, Kuhs, Krystle, Lewis, James S, Mirabello, Lisa, Yeager, Meredith, Boland, Joseph F, Bass, Sara, Steinberg, Mia, Cullen, Michael, Lawrence, Michael S, Ferris, Robert L
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Biology, Genetics and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8014522/
https://ncbi.nlm.nih.gov/pubmed/33075810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgaa111
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