Deprotection of centromeric cohesin at meiosis II requires APC/C activity but not kinetochore tension

Genome haploidization involves sequential loss of cohesin from chromosome arms and centromeres during two meiotic divisions. At centromeres, cohesin's Rec8 subunit is protected from separase cleavage at meiosis I and then deprotected to allow its cleavage at meiosis II. Protection of centromeri...

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Bibliographic Details
Published in:EMBO J
Main Authors: Mengoli, Valentina, Jonak, Katarzyna, Lyzak, Oleksii, Lamb, Mahdi, Lister, Lisa M, Lodge, Chris, Rojas, Julie, Zagoriy, Ievgeniia, Herbert, Mary, Zachariae, Wolfgang
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8013787/
https://ncbi.nlm.nih.gov/pubmed/33644894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106812
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