Model‐informed drug repurposing: A pharmacometric approach to novel pathogen preparedness, response and retrospection

During a pandemic caused by a novel pathogen (NP), drug repurposing offers the potential of a rapid treatment response via a repurposed drug (RD) while more targeted treatments are developed. Five steps of model‐informed drug repurposing (MIDR) are discussed: (i) utilize RD product label and in vitr...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Dodds, Michael, Xiong, Yuan, Mouksassi, Samer, Kirkpatrick, Carl M., Hui, Katrina, Doyle, Eileen, Patel, Kashyap, Cox, Eugène, Wesche, David, Brown, Fran, Rayner, Craig R.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8013376/
https://ncbi.nlm.nih.gov/pubmed/33534138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14760
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