Functional Characterization of the Effects of N-acetyltransferase 2 Alleles on N-acetylation of Eight Drugs and Worldwide Distribution of Substrate-Specific Diversity

Variability in the enzymatic activity of N-acetyltransferase 2 (NAT2) is an important contributor to interindividual differences in drug responses. However, there is little information on functional differences in N-acetylation activities according to NAT2 phenotypes, i.e., rapid, intermediate, slow...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Fukunaga, Koya, Kato, Ken, Okusaka, Takuji, Saito, Takeo, Ikeda, Masashi, Yoshida, Teruhiko, Zembutsu, Hitoshi, Iwata, Nakao, Mushiroda, Taisei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8012690/
https://ncbi.nlm.nih.gov/pubmed/33815485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2021.652704
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