Age-dependent ataxia and neurodegeneration caused by an αII spectrin mutation with impaired regulation of its calpain sensitivity

The neuronal membrane-associated periodic spectrin skeleton (MPS) contributes to neuronal development, remodeling, and organization. Post-translational modifications impinge on spectrin, the major component of the MPS, but their role remains poorly understood. One modification targeting spectrin is...

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Vydáno v:Sci Rep
Hlavní autoři: Miazek, Arkadiusz, Zalas, Michał, Skrzymowska, Joanna, Bogin, Bryan A., Grzymajło, Krzysztof, Goszczynski, Tomasz M., Levine, Zachary A., Morrow, Jon S., Stankewich, Michael C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8012654/
https://ncbi.nlm.nih.gov/pubmed/33790315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86470-1
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