Type I interferons affect the metabolic fitness of CD8(+) T cells from patients with systemic lupus erythematosus

The majority of patients with systemic lupus erythematosus (SLE) have high expression of type I IFN-stimulated genes. Mitochondrial abnormalities have also been reported, but the contribution of type I IFN exposure to these changes is unknown. Here, we show downregulation of mitochondria-derived gen...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Buang, Norzawani, Tapeng, Lunnathaya, Gray, Victor, Sardini, Alessandro, Whilding, Chad, Lightstone, Liz, Cairns, Thomas D., Pickering, Matthew C., Behmoaras, Jacques, Ling, Guang Sheng, Botto, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8012390/
https://ncbi.nlm.nih.gov/pubmed/33790300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22312-y
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