PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma

OBJECTIVE: Neoadjuvant chemoradiotherapy (neo-CRT) prior to surgery is the standard of care for oesophageal adenocarcinoma (OAC) patients. Unfortunately, most patients fail to respond to treatment. MiR-187 was previously shown to be downregulated in neo-CRT non-responders, whist in vitro miR-187 ove...

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Vydáno v:Br J Radiol
Hlavní autoři: Edge, Sarah D, Renard, Isaline, Pyne, Emily, Li, Chun, Moody, Hannah, Roy, Rajarshi, Beavis, Andrew W, Archibald, Stephen J, Cawthorne, Christopher J, Maher, Stephen G, Pires, Isabel M
Médium: Artigo
Jazyk:Inglês
Vydáno: The British Institute of Radiology. 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011247/
https://ncbi.nlm.nih.gov/pubmed/33434085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1259/bjr.20201191
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