An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function

Mitochondria maintain a distinct pool of ribosomal machinery, including tRNAs and tRNAs activating enzymes, such as mitochondrial tyrosyl-tRNA synthetase (YARS2). Mutations in YARS2, which typically lead to the impairment of mitochondrial protein synthesis, have been linked to an array of human dise...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jin, Xiaofen, Zhang, Zengming, Nie, Zhipeng, Wang, Chenghui, Meng, Feilong, Yi, Qiuzi, Chen, Mengquan, Sun, Jiji, Zou, Jian, Jiang, Pingping, Guan, Min-Xin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010715/
https://ncbi.nlm.nih.gov/pubmed/33610547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100437
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